Methyl iodide → Ethyl 1-methyl-2-oxocyclopentane-1-carboxylate
반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[C:7]([O:9][CH2:10][CH3:11])=[O:8].[C:12]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[CH3:12][C:3]1([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]참가 물질
5
실험 절차
To a suspension of ethyl 2-oxocyclopentanecarboxylate (20.3 g, 0.130 mol) and K2CO3 (53.8 g, 0.390 mol) in acetone (90 mL) was added MeI (36.9 g, 0.250 mol) at ambient temperature. The reaction mixture was stirred for 30 min at ambient temperature and then heated under reflux for 1 h. Acetone was removed under reduced pressure and diethyl ether (200 mL) was added to the residue. The resulting mixture was stirred for 15 min and filtered. The filtrate was concentrated under reduced pressure followed by distillation under vacuum to afford ethyl 1-methyl-2-oxocyclopentanecarboxylate (20.5 g, 92% yield).
후처리
- temperatureheated
- temperatureunder reflux for 1 h
- customAcetone was removed under reduced pressure and diethyl ether (200 mL)
- additionwas added to the residue
- stirringThe resulting mixture was stirred for 15 min
- filtrationfiltered
- concentrationThe filtrate was concentrated under reduced pressure
- distillationfollowed by distillation under vacuum
출처 및 근거
- ORD 기록
- ord-a983ff367a9f4ab487ef0b59ea207ddd
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434761B2
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