Pyrrolidine → 2-Methyl-4-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

HRID 588461

반응식

HRID 588461 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][N:7]1[C:11]([C:12](=[O:28])[NH:13][C:14]2[CH:15]=[CH:16][C:17]3[N:18]([N:20]=[C:21]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)[N:22]=3)[CH:19]=2)=[C:10]([C:29](O)=[O:30])[CH:9]=[N:8]1>>[N:23]1([C:21]2[N:22]=[C:17]3[CH:16]=[CH:15][C:14]([NH:13][C:12]([C:11]4[N:7]([CH3:6])[N:8]=[CH:9][C:10]=4[C:29]([N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[O:30])=[O:28])=[CH:19][N:18]3[N:20]=2)[CH2:27][CH2:26][CH2:25][CH2:24]1

참가 물질

3

반응물 2

HCID 31268PyrrolidineHCID 894640281-Methyl-5-(2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

생성물 1

HCID 715389792-Methyl-4-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-amide

실험 절차

Using pyrrolidine and 1-Methyl-5-(2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. White solid (46 mg, 58%). MS: m/z=409 (M+H+).

출처 및 근거

ORD 기록
ord-1692acccbfd6413a8b5dd7b1edfd79cf
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227970B2

연결된 노트

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