Hydrochloric Acid → 5-(1-Aminoethyl)thiophene-2-carboxylate hydrochloride

HRID 588502노트

반응식

HRID 588502 반응식
C(OC([NH:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18]C)=[O:17])=[CH:14]N=1)[CH3:10])=O)(C)(C)C.[ClH:20].[CH3:21]O>O1CCOCC1>[ClH:20].[NH2:8][CH:9]([C:11]1[S:12][C:13]([C:16]([OH:18])=[O:17])=[CH:14][CH:21]=1)[CH3:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 67397774Methyl 2-(1-((tert-butoxycarbonyl)amino)ethyl)thiazole-5-carboxylate

생성물 1

HCID 673953435-(1-Aminoethyl)thiophene-2-carboxylate hydrochloride수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of methyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate (0.9 g, 3 mmol) in MeOH (5 mL) was added 4M HCl in dioxane (4 mL). The reaction was stirred overnight at room temperature. The reaction was evaporated to dryness to afford 5-(1-aminoethyl)thiophene-2-carboxylate hydrochloride (0.7 g, 100%).

후처리

  1. customThe reaction was evaporated to dryness

출처 및 근거

ORD 기록
ord-c3649d2de7fc4711a31f99196f4546e7
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227951B2

반응 노트

불러오는 중…