Acetic Anhydride → Methyl 2-[5-acetamido-3-(3-pyridyl)pyrazol-1-yl]acetate

HRID 588592노트

반응식

HRID 588592 반응식
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][C:9]1[N:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[N:12]=[C:11]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:10]=1>N1C=CC=CC=1>[C:1]([NH:8][C:9]1[N:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[N:12]=[C:11]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH:10]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 86717291Methyl 2-[5-amino-3-(3-pyridyl)pyrazol-1-yl]acetate

생성물 1

HCID 86717292Methyl 2-[5-acetamido-3-(3-pyridyl)pyrazol-1-yl]acetate수율 71.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Acetic anhydride (431 μL, 4.4 mmol) was added dropwise to a solution of methyl 2-[5-amino-3-(3-pyridyl)pyrazol-1-yl]acetate (510 mg, 2.2 mmol) in pyridine (1.7 mL) at 0° C. under an atmosphere of nitrogen. Upon complete addition, the reaction mixture was warmed to room temperature and stirred for 16 h. The reaction mixture was filtered and the solid was washed with diethyl ether to provide the title compound as a white solid (430 mg).

후처리

  1. additionUpon complete addition
  2. filtrationThe reaction mixture was filtered
  3. washthe solid was washed with diethyl ether

출처 및 근거

ORD 기록
ord-1cee3b9b3d5d4ef6a26a29876c158321
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227976B2

반응 노트

불러오는 중…