Hydrochloric Acid → 2-Amino-6-bromo-4-fluoro-3-nitrophenol

HRID 589132노트

반응식

HRID 589132 반응식
[Br:1][C:2]1[C:7]([OH:8])=[C:6]([N+:9]([O-])=O)[C:5]([N+:12]([O-:14])=[O:13])=[C:4]([F:15])[CH:3]=1.Cl>CO.O>[NH2:9][C:6]1[C:5]([N+:12]([O-:14])=[O:13])=[C:4]([F:15])[CH:3]=[C:2]([Br:1])[C:7]=1[OH:8]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 90410240HCID 90410240, 화합물

생성물 1

HCID 904098182-Amino-6-bromo-4-fluoro-3-nitrophenol

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

6-Bromo-4-fluoro-2,3-dinitrophenol (4.4 g, 16 mmol) was stirred in methanol (88 mL) and 12.0 M hydrogen chloride in water (40 mL), followed by addition of stannous chloride dihydrate (11 g, 47 mmol) and the mixture was stirred at room temperature for 15 min. The mixture was diluted with water and extracted with ethyl acetate. The organic layer was separated and concentrated. Purification on silica gel eluting ethyl acetate in hexanes gave the amine product.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organic layer was separated
  3. concentrationconcentrated
  4. customPurification on silica gel
  5. washeluting ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-a566e1f55c614dc2855a42c62da85f4a
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09227985B2

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