Water → 3-(3-Pyridinyl)-5-isoxazolecarboxylic acid

HRID 589622노트

반응식

HRID 589622 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([O:14]CC)=[O:13])[O:9][N:8]=2)[CH:2]=1.O.[OH-].[Na+]>O1CCOCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:11]=[C:10]([C:12]([OH:14])=[O:13])[O:9][N:8]=2)[CH:2]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 776521HCID 776521, 화합물

생성물 1

HCID 290785823-(3-Pyridinyl)-5-isoxazolecarboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

300 mg (1.38 mmol) of ethyl 3-(pyridin-3-yl)-1,2-oxazole-5-carboxylate (for preparation see Chem. Heterocyclic Comp. 2000, 36, 1226-1231) were dissolved in 20 ml of dioxane. While cooling with ice, 7 ml of water and 0.35 ml of 45% aqueous sodium hydroxide solution were added to the solution. The mixture was stirred at room temperature for two hours, then the dioxane was removed on a rotary evaporator under reduced pressure. Ice-water was added to the residue, and it was acidified with concentrated hydrochloric acid. The solution was stirred at room temperature overnight, and the precipitated solid was filtered off with suction and dried.

후처리

  1. additionwere added to the solution
  2. customthe dioxane was removed on a rotary evaporator under reduced pressure
  3. additionIce-water was added to the residue, and it
  4. stirringThe solution was stirred at room temperature overnight
  5. filtrationthe precipitated solid was filtered off with suction
  6. customdried

출처 및 근거

ORD 기록
ord-f795165e54a5481097bbdd1e2d72c3c2
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233951B2

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