5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride → HCID 178432000, 화합물

HRID 589710

반응식

HRID 589710 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10](Cl)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH:18]=3)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1

참가 물질

3

반응물 2

HCID 27745865-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride2회HCID 178507542HCID 178507542, 화합물

생성물 1

HCID 178432000HCID 178432000, 화합물수율 36%

실험 절차

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-fluoro-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 14) (26 mg, 0.10 mmol) and 5-(3-amino-phenyl)tetrazole (31 mg, 0.19 mmol). The title compound was obtained in 36% yield (13.9 mg). MS (ESI+) calcd for C16H12FN5O2S2 389.041644, found 389.042334.

후처리

  1. customThe product was prepared

출처 및 근거

ORD 기록
ord-e81738f6c1474d4689b642b53cd9f48a
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233946B2

연결된 노트

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