4-Methoxy-3-methylbenzyl chloride → (RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-[(4-methoxy-3-methylphenyl)methoxy]-3-isoquinolinecarboxylic acid, ethyl ester

HRID 5900

반응식

HRID 5900 반응식
[C:1]1([CH:7]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:8]([N:10]2[CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:26][CH3:27])[C:16]=3[OH:25])[CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:34][O:35][C:36]1[CH:43]=[CH:42][C:39]([CH2:40]Cl)=[CH:38][C:37]=1[CH3:44]>>[C:28]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]([N:10]2[CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:26][CH3:27])[C:16]=3[O:25][CH2:40][C:39]3[CH:42]=[CH:43][C:36]([O:35][CH3:34])=[C:37]([CH3:44])[CH:38]=3)[CH2:11]2)=[O:9])[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

참가 물질

3

반응물 2

HCID 1437424-Methoxy-3-methylbenzyl chlorideHCID 15296729(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-5-hydroxy-6-methoxy-3-isoquinolinecarboxylic acid, ethyl ester

생성물 1

HCID 15230314(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-[(4-methoxy-3-methylphenyl)methoxy]-3-isoquinolinecarboxylic acid, ethyl ester

실험 절차

This compound is prepared from the phenol derivative of Example 31 and 4-methoxy-3-methyl benzyl chloride by a procedure similar to that in Example 32. The product is purified by silica gel chromatography; tlc (1:1 ethyl-acetate/hexane), one spot, Rf 0.7.

후처리

  1. customThe product is purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-5863e731e9c84c6190da1db07ffc1880
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246943

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