Ethyl Acetoacetate → HCID 118358749, 화합물

HRID 590566

반응식

HRID 590566 반응식
[CH3:1][O:2][C:3]([C:5]1[C@H](C2C=CC(F)=CC=2Cl)[N:7]=[C:8]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)[NH:9][C:10]=1[CH2:11][Br:12])=[O:4].[C:26](OCC)(=O)CC(C)=O.[Cl:35][C:36]1[C:43]([F:44])=[CH:42][CH:41]=[CH:40][C:37]=1[CH:38]=O.ClC1C=C(F)C=CC=1C=O>>[Br:12][CH2:11][C:10]1[NH:9][C:8]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[N:7][C@@H:38]([C:37]2[CH:40]=[CH:41][CH:42]=[C:43]([F:44])[C:36]=2[Cl:35])[C:5]=1[C:3]([O:2][CH2:1][CH3:26])=[O:4]

참가 물질

5

반응물 4

HCID 8868Ethyl AcetoacetateHCID 1450242-Chloro-4-fluorobenzaldehydeHCID 149449052-Chloro-3-fluorobenzaldehydeHCID 89995948Methyl (R)-6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

생성물 1

HCID 118358749HCID 118358749, 화합물

실험 절차

Compound C-1 was prepared in analogy to compound C by using ethyl acetoacetate and 2-chloro-3-fluorobenzaldehyde instead of methyl acetoacetate and 2-chloro-4-fluorobenzaldehyde.

출처 및 근거

ORD 기록
ord-c8c60468242641d59080dd20d745d105
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09233978B2

연결된 노트

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