Cesium carbonate → 4-(((3,3-Difluorocyclobutyl)methoxy)methyl)-6-(1-ethoxyvinyl)-N-(3-methoxy-4-(6-methylpyridazin-4-yl)phenyl)pyrimidin-2-amine

반응식

Cl[C:2]1[N:7]=[C:6]([CH2:8][O:9][CH2:10][CH:11]2[CH2:14][C:13]([F:16])([F:15])[CH2:12]2)[CH:5]=[C:4]([C:17]([O:19][CH2:20][CH3:21])=[CH2:18])[N:3]=1.[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][C:30]=1[C:31]1[CH:36]=[C:35]([CH3:37])[N:34]=[N:33][CH:32]=1)[NH2:27].C(=O)([O-])[O-].[Cs+].[Cs+].C1(C2C=CC=CC=2)C=CC=CC=1P(C1CCCCC1)C1CCCCC1>O1CCOCC1.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[F:15][C:13]1([F:16])[CH2:14][CH:11]([CH2:10][O:9][CH2:8][C:6]2[CH:5]=[C:4]([C:17]([O:19][CH2:20][CH3:21])=[CH2:18])[N:3]=[C:2]([NH:27][C:26]3[CH:28]=[CH:29][C:30]([C:31]4[CH:36]=[C:35]([CH3:37])[N:34]=[N:33][CH:32]=4)=[C:24]([O:23][CH3:22])[CH:25]=3)[N:7]=2)[CH2:12]1