N-bromobutanimide → methyl 2-(2-bromo-1-methyl-1H-indol-3-yl)pentanoate

HRID 590999노트

반응식

HRID 590999 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([CH2:16][CH2:17][CH3:18])[C:12]([O:14][CH3:15])=[O:13])=[CH:3]1.[Br:19]N1C(=O)CCC1=O>ClC(Cl)(Cl)Cl>[Br:19][C:3]1[N:2]([CH3:1])[C:10]2[C:5]([C:4]=1[CH:11]([CH2:16][CH2:17][CH3:18])[C:12]([O:14][CH3:15])=[O:13])=[CH:6][CH:7]=[CH:8][CH:9]=2

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 70817995methyl 2-(1-methyl-1H-indol-3-yl)pentanoate

생성물 1

HCID 70819053methyl 2-(2-bromo-1-methyl-1H-indol-3-yl)pentanoate

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A solution of methyl 2-(1-methyl-1H-indol-3-yl)pentanoate (12b) (860 mg, 3.44 mmol) and N-bromosuccinimide (623 mg, 3.5 mmol) in tetrachloromethane (20 mL) was stirred at room temperature for 5 hours. The mixture was then filtered and the filtrate was washed with water (10 mL), brine (10 mL), dried over sodium sulfate, filtered and evaporated under reduced pressure to afford the desired product (12c) as a brown oil without further purification (1.13 g, 3.44 mmol, 100%).

후처리

  1. filtrationThe mixture was then filtered
  2. washthe filtrate was washed with water (10 mL), brine (10 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b1dfad4959c743908bde6e7ed3469dce
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238026B2

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