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Methanol → (6-((2,4-Dichlorobenzyl)oxy)-1,1-dioxido-1-benzothiophen-3-yl)acetic acid

HRID 591474
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HRID 591474 반응식
C([O:3][C:4](=[O:27])[CH2:5][C:6]1[C:10]2[CH:11]=[CH:12][C:13]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=3[Cl:24])=[CH:14][C:9]=2[S:8](=[O:26])(=[O:25])[CH:7]=1)C.C1COCC1.CO.O.[OH-].[Li+]>O>[Cl:24][C:18]1[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:17]=1[CH2:16][O:15][C:13]1[CH:12]=[CH:11][C:10]2[C:6]([CH2:5][C:4]([OH:27])=[O:3])=[CH:7][S:8](=[O:26])(=[O:25])[C:9]=2[CH:14]=1
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참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 71721636Ethyl(6-((2,4-dichlorobenzyl)oxy)-1,1-dioxido-1-benzothiophen-3-yl)acetate

생성물 1

HCID 71721637(6-((2,4-Dichlorobenzyl)oxy)-1,1-dioxido-1-benzothiophen-3-yl)acetic acid수율 53.5%

시약·촉매·용매 1

HCID 962
Water
용매

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온도
25 °C

실험 절차

To a mixture of ethyl(6-((2,4-dichlorobenzyl)oxy)-1,1-dioxido-1-benzothiophen-3-yl)acetate (8.00 g), THF (64 mL), MeOH (64 mL) and H2O (32 mL) was added lithium hydroxide hydrate (1.58 g) and the resulting mixture was stirred at 25° C. for 16 h. The solvent was removed under reduced pressure. The residue was suspended in water, and the mixture was acidified by 6N HCl. The resulting solid was collected by filtration, and dried under reduced pressure to give the title compound (4.00 g).

후처리

  1. customThe solvent was removed under reduced pressure
  2. filtrationThe resulting solid was collected by filtration
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-cd8669838b1341c8aef62b44d3132c90
출처 데이터셋
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09238639B2

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