Hydrochloric Acid → (4-Ethyl-2-methyl-1,3-thiazol-5-yl)methanol

HRID 591497노트

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HRID 591497 반응식
[CH2:1]([C:3]1[N:4]=[C:5]([CH3:11])[S:6][C:7]=1[C:8](O)=[O:9])[CH3:2].Cl>C1COCC1>[CH2:1]([C:3]1[N:4]=[C:5]([CH3:11])[S:6][C:7]=1[CH2:8][OH:9])[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 146487654-Ethyl-2-methyl-1,3-thiazole-5-carboxylic acid

생성물 1

HCID 37134637(4-Ethyl-2-methyl-1,3-thiazol-5-yl)methanol수율 34%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a borane tetrahydrofuran complex solution (1.2 M in THF, 5 mL) was added 4-ethyl-2-methylthiazole-5-carboxylic acid (400 mg) at 0° C. The mixture was stirred at 0° C. to room temperature under argon atmosphere overnight. To the mixture was added 1N HCl at room temperature, and the mixture was extracted with EtOAc. The organic layer was separated, washed successively with brine and water, dried over Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (125 mg).

후처리

  1. extractionthe mixture was extracted with EtOAc
  2. customThe organic layer was separated
  3. washwashed successively with brine and water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by silica gel column chromatography (EtOAc/hexane)

출처 및 근거

ORD 기록
ord-0c58eb5110d94b3c996c563aa287aedd
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238639B2

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