Dimethylformamide → 6-Acetylbenzoselenazolinone

반응식

[Cl-].[Al+3].[Cl-].[Cl-].CN(C)C=O.[Se:10]1(=[O:19])[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[CH:11]1.[C:20](Cl)(=[O:22])[CH3:21]>>[C:20]([C:16]1[CH:17]=[CH:18][C:13]2[N:12]=[CH:11][Se:10](=[O:19])[C:14]=2[CH:15]=1)(=[O:22])[CH3:21]

참가 물질

반응물 4

HCID 6228Dimethylformamide

HCID 6367Acetyl chloride

HCID 6451240Aluminum(III) Chloride

HCID 87879929Benzoselenazolinone

생성물 1

HCID 1317181736-Acetylbenzoselenazolinone

실험 절차

12 grams (0.09 mol) of aluminum chloride are introduced into a ground-necked flask. 3.1 cm3 (0.04 mol) of dimethylformamide are added dropwise with stirring. After cooling, two grams (0.01 mol) of benzoselenazolinone are added and the mixture is homogenized. It is heated to 70°-80° C. on an oil bath with stirring, and 0.01 to 0.012 mol of acetyl chloride is then added. heating is maintained at a temperature of 80°-90° C. for a time T of approximately 4 h 30 min. The mixture is hydrolyzed on crushed ice. The product is drained, dried, and washed with boiling cyclohexane and recrystallized in toluene.