Cesium carbonate → 4-(4,4-Difluoropiperidin-1-yl)-N-(3-methoxy-4-(6-methylpyridazin-4-yl)phenyl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-2-amine

반응식

Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][C:11]([F:15])([F:14])[CH2:10][CH2:9]2)[CH:5]=[C:4]([CH2:16][O:17][CH2:18][C:19]([F:22])([F:21])[F:20])[N:3]=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH:29]=[CH:30][C:31]=1[C:32]1[CH:37]=[C:36]([CH3:38])[N:35]=[N:34][CH:33]=1)[NH2:28].C(=O)([O-])[O-].[Cs+].[Cs+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C=CC=CC=2)CCCCC1>O1CCOCC1.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[F:14][C:11]1([F:15])[CH2:12][CH2:13][N:8]([C:6]2[CH:5]=[C:4]([CH2:16][O:17][CH2:18][C:19]([F:22])([F:21])[F:20])[N:3]=[C:2]([NH:28][C:27]3[CH:29]=[CH:30][C:31]([C:32]4[CH:37]=[C:36]([CH3:38])[N:35]=[N:34][CH:33]=4)=[C:25]([O:24][CH3:23])[CH:26]=3)[N:7]=2)[CH2:9][CH2:10]1