Water → 4-Acetamido-3-iodobenzaldehyde

HRID 591679노트

반응식

HRID 591679 반응식
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([I:13])[CH:4]=1.O>CS(C)=O>[CH:2]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([I:13])[CH:4]=1)=[O:1]

참가 물질

4

반응물 2

HCID 962WaterHCID 66745042N-(4-(Hydroxymethyl)-2-iodophenyl)acetamide

생성물 1

HCID 229919464-Acetamido-3-iodobenzaldehyde

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

To a solution of IBX (0.93 g, 3.3 mmol) in dimethylsulfoxide (3.5 mL) was added N-(4-hydroxymethyl-2-iodo-phenyl)-acetamide (0.87 g, 3.0 mmol) and the reaction mixture was stirred at room temperature for 1 hour. Water (50 mL) was added and the solid was separated by filtration, and washed with ethyl acetate (20 mL). The filtrate was collected and extracted with ethyl acetate (200 mL). The organic phase was washed with brine (100 mL) and dried over anhydrous Na2SO4. Removal of solvent gave N-(4-formyl-2-iodo-phenyl)-acetamide as a light brown solid. Yield: 0.82 g (95%).

후처리

  1. customthe solid was separated by filtration
  2. washwashed with ethyl acetate (20 mL)
  3. customThe filtrate was collected
  4. extractionextracted with ethyl acetate (200 mL)
  5. washThe organic phase was washed with brine (100 mL)
  6. dry with materialdried over anhydrous Na2SO4
  7. customRemoval of solvent

출처 및 근거

ORD 기록
ord-932f32110be646afa950cb72c7fb2cf3
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238640B2

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