Acetonitrile → 4-[1-Methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo-1,6-dihydropyridin-3-yl]-2-[(1S,11R)-7-oxo-3,6-diazatetracyclo[9.2.1.02,10.03,8]tetradeca-2(10),8-dien-6-yl]pyridine-3-carbaldehyde

반응식

C(#N)C.Cl[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([N:11]2[C:23](=[O:24])[C:22]3[N:14]([C:15]4[C@@H:16]5[CH2:25][C@H:19]([C:20]=4[CH:21]=3)[CH2:18][CH2:17]5)[CH2:13][CH2:12]2)[C:6]=1[CH:26]=[O:27].[CH3:28][N:29]1[CH:34]=[C:33](B2OC(C)(C)C(C)(C)O2)[CH:32]=[C:31]([NH:44][C:45]2[CH:50]=[CH:49][C:48]([N:51]3[CH2:56][CH2:55][N:54]([CH:57]4[CH2:60][O:59][CH2:58]4)[CH2:53][C@@H:52]3[CH3:61])=[CH:47][N:46]=2)[C:30]1=[O:62].C([O-])(=O)C.[K+]>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].O>[CH3:28][N:29]1[C:30](=[O:62])[C:31]([NH:44][C:45]2[CH:50]=[CH:49][C:48]([N:51]3[CH2:56][CH2:55][N:54]([CH:57]4[CH2:58][O:59][CH2:60]4)[CH2:53][C@@H:52]3[CH3:61])=[CH:47][N:46]=2)=[CH:32][C:33]([C:5]2[CH:10]=[CH:9][N:8]=[C:7]([N:11]3[C:23](=[O:24])[C:22]4[N:14]([C:15]5[C@@H:16]6[CH2:25][C@H:19]([C:20]=5[CH:21]=4)[CH2:18][CH2:17]6)[CH2:13][CH2:12]3)[C:6]=2[CH:26]=[O:27])=[CH:34]1