1-Pyrrolidinesulfonyl chloride → 6-Chloro-2-[5-(pyrrolidine-1-sulfonyloxy)-pyridin-3-yl]-indole-1-carboxylic acid tert-butyl ester

HRID 593615

반응식

HRID 593615 반응식
[N:1]1([S:6](Cl)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:10]([O:14][C:15]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([Cl:26])[CH:24]=2)[CH:19]=[C:18]1[C:27]1[CH:28]=[N:29][CH:30]=[C:31]([OH:33])[CH:32]=1)=[O:16])([CH3:13])([CH3:12])[CH3:11]>>[C:10]([O:14][C:15]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([Cl:26])[CH:24]=2)[CH:19]=[C:18]1[C:27]1[CH:28]=[N:29][CH:30]=[C:31]([O:33][S:6]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:8])=[O:7])[CH:32]=1)=[O:16])([CH3:13])([CH3:11])[CH3:12]

참가 물질

3

반응물 2

HCID 64839021-Pyrrolidinesulfonyl chlorideHCID 582155456-Chloro-2-(5-hydroxy-pyridin-3-yl)-indole-1-carboxylic acid tert-butyl ester

생성물 1

HCID 582157706-Chloro-2-[5-(pyrrolidine-1-sulfonyloxy)-pyridin-3-yl]-indole-1-carboxylic acid tert-butyl ester

실험 절차

1-Pyrrolidine-sulfonyl chloride and 6-chloro-2-(5-hydroxy-pyridin-3-yl)-indole-1-carboxylic acid tert-butyl ester (Example 160a) are processed according to the method described in Example 160b to give 6-chloro-2-[5-(pyrrolidine-1-sulfonyloxy)-pyridin-3-yl]-indole-1-carboxylic acid tert-butyl ester, which is taken onto the next step without further purification. MS (ESI) m/z 478.1 (M+H)+.

출처 및 근거

ORD 기록
ord-b0284560b9f64148950560c56d05a055
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242963B2

연결된 노트

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