[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=2)[C:9](OCC)=[O:10])=[CH:4][N:3]=[CH:2]1.CC(C[AlH]CC(C)C)C.[OH-].[Na+].C([O-])(O)=O.[Na+]>C1(C)C=CC=CC=1.O>[S:1]1[C:5]([C:6]2[CH:7]=[C:8]([CH2:9][OH:10])[CH:14]=[CH:15][CH:16]=2)=[CH:4][N:3]=[CH:2]1A cooled (−78° C.) solution of ethyl 3-(thiazol-5-yl)benzoate (553 mg; 2.37 mmol) in anh. toluene (8 ml) was treated with a solution of 1 M DIBAH in toluene (7.12 ml; 7.12 mmol), and the resulting mixture was further stirred at −78° C., under nitrogen, for 5 min., and then at 0° C. for 30 min. The mixture was then treated successively with water (35 ml), 1 M aq. NaOH (11 ml), and aq. sat. NaHCO3 (30 ml). The separated aq. layer was further extracted with Et2O (2×100 ml). The mixed organic layers were then dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure. Purification by FC (DCM/MeOH=20/1) afforded (3-(thiazol-5-yl)phenyl)methanol as an orange oil. LC-MS (conditions A): tR=0.49 min.; [M+H]+: 192.10 g/mol.
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