Hydrochloric Acid → Methyl 4-([1,1'-biphenyl]-2-yl)-4-aminobutanoate

HRID 594353노트

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HRID 594353 반응식
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([NH:14]S(C(C)(C)C)=O)[CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11].Cl.O1CCOCC1>CO>[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([NH2:14])[CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 69082814Methyl 4-([1,1'-biphenyl]-2-yl)-4-(1,1-dimethylethylsulfinamido)butanoate

생성물 1

HCID 69084601Methyl 4-([1,1'-biphenyl]-2-yl)-4-aminobutanoate

시약·촉매·용매 1

HCID 887Methanol용매

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온도
0 °C

실험 절차

A cooled (0° C.) slightly yellow solution of methyl 4-([1,1′-biphenyl]-2-yl)-4-(1,1-dimethylethylsulfinamido)butanoate (330 mg; 0.88 mmol) in MeOH (4 ml) was treated dropwise with a solution of 4 M HCl in 1,4-dioxane (0.44 ml; 1.77 mmol). The resulting yellow mixture was further stirred at 0° C., under nitrogen, for 10 min., and then at rt for 1 h. The reaction mixture was then concentrated to dryness under reduced pressure and the oily residue was further dried under HV to give the chlorhydrate salt of methyl 4-([1,1′-biphenyl]-2-yl)-4-aminobutanoate. LC-MS (conditions A): tR=0.56 min.; [M+H]+: 270.06 g/mol.

후처리

  1. waitat rt for 1 h
  2. concentrationThe reaction mixture was then concentrated to dryness under reduced pressure
  3. customthe oily residue was further dried under HV

출처 및 근거

ORD 기록
ord-77b39a53ee474b7499cc756eda84f045
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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