4-Fluorobenzyl bromide → 5-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one

HRID 594615

반응식

HRID 594615 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:15][C:14](=[O:16])[CH2:13][CH2:12]1.Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:15]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[C:14](=[O:16])[CH2:13][CH2:12]1

참가 물질

3

반응물 2

HCID 680214-Fluorobenzyl bromideHCID 690809115-(2,6-Dimethoxyphenyl)pyrrolidin-2-one

생성물 1

HCID 690857565-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one

실험 절차

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-fluorobenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.71 min.; [M+H]+: 330.24 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-12aed9d020874c699f39475e1f7b47d3
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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