Sodium Carbonate → Mellein

HRID 594923노트

반응식

HRID 594923 반응식
CCCCCCCCCCCCCCCCCCN[C:20]([CH2:22][CH2:23][C:24]1[CH:29]=[C:28](C(C)(C)C)[C:27](O)=[C:26](C(C)(C)C)[CH:25]=1)=O.[O-:39][Mn](=O)(=O)=O.[K+].[C:45]([O-])([O-:47])=[O:46].[Na+].[Na+]>CC(O)=O.O>[CH3:20][CH:22]1[O:47][C:45](=[O:46])[C:29]2[C:28]([OH:39])=[CH:27][CH:26]=[CH:25][C:24]=2[CH2:23]1

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 516875Potassium PermanganateHCID 197363073,5-Bis(1,1-dimethylethyl)-4-hydroxy-N-octadecylbenzenepropanamide

생성물 1

HCID 28516Mellein

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매2회

실험 절차

To a stirred solution of AO-1 (16.5 g, 83.0 mmol) in AcOH (150 mL) kept below 10° C. is added a solution of KMnO4 (14.5 g, 92.0 mmol) in H2O (150 mL) dropwise. The reaction mixture is stirred for 30 min. The mixture is diluted with water, basified by addition of saturated aq Na2CO3 and extracted with EtOAc. The solution is concentrated and the residue is purified by SFC to yield AO-2.

후처리

  1. customkept below 10° C.
  2. extractionextracted with EtOAc
  3. concentrationThe solution is concentrated
  4. customthe residue is purified by SFC

출처 및 근거

ORD 기록
ord-d400661187fc4bccad7895e0d676b0bc
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242989B2

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