Phosphorus tribromide → HCID 67112138, 화합물
반응식
O[CH2:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8]([NH2:10])=[O:9].P(Br)(Br)[Br:15]>ClCCl>[Br:15][CH2:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8]([NH2:10])=[O:9]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
2-(3-(hydroxymethyl)phenoxy)acetamide (320 mg, 1.76 mmol) was suspended in dichloromethane (12 mL) and the suspension cooled to 0° C. (ice bath). Phosphorus tribromide (1.5 eq) was added slowly and the reaction allowed to warm to rt. After stirring for 18 h the reaction was quenched by addition of NaHCO3 (sat., aq). The product was extracted with dichloromethane, dried (Na2SO4), filtered and concentrated in vacuo to afford 2-(3-(bromomethyl)phenoxy)acetamide as a white solid.
후처리
- temperatureto warm to rt
- customwas quenched by addition of NaHCO3 (sat., aq)
- extractionThe product was extracted with dichloromethane
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-3457c9591d86463eab43a351505e0c1c
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09242987B2
반응 노트
불러오는 중…