Acetic Acid → 5,7-Dihydrothieno[3,4-d]pyrimidine-2,4-diol

HRID 595048노트

반응식

HRID 595048 반응식
C(S[C:4]1[NH:5][C:6](=[O:13])[C:7]2[CH2:12][S:11][CH2:10][C:8]=2[N:9]=1)C.Cl.CC(O)=[O:17]>O>[NH:9]1[C:8]2[CH2:10][S:11][CH2:12][C:7]=2[C:6](=[O:13])[NH:5][C:4]1=[O:17]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 135449010HCID 135449010, 화합물

생성물 1

HCID 103521145,7-Dihydrothieno[3,4-d]pyrimidine-2,4-diol수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To the suspension of 2-(ethylthio)thieno[3,4-d]pyrimidin-4-(3H, 5H, 7H)-one (2.88 g, 13.45 mmol) in water (20 mL) was added 2.0 mL of cone. HCl and 4.0 mL of AcOH. The reaction was heated at reflux overnight then cooled and the solid collected by filtration, washed with water and methanol, evaporated and dried to obtain a white solid thieno[3,4-d]pyrimidine-2,4-(1H, 3H, 5H, 7H)-dione (1.80 g, 80%). Without further purification, the crude product was used directly in the next step.

후처리

  1. additionwas added 2.0 mL of cone
  2. temperatureThe reaction was heated
  3. temperatureat reflux overnight
  4. temperaturethen cooled
  5. filtrationthe solid collected by filtration
  6. washwashed with water and methanol
  7. customevaporated
  8. customdried

출처 및 근거

ORD 기록
ord-e4e56741e6b54b6a9f8cb47a7dfc6b7f
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242993B2

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