Acetic Acid → HCID 89494514, 화합물
반응식
C(S[C:4]1[NH:5][C:6](=[O:14])[C:7]2[CH2:12][S:11][CH:10]([CH3:13])[C:8]=2[N:9]=1)C.Cl.CC(O)=[O:18]>O>[CH3:13][CH:10]1[C:8]2[NH:9][C:4](=[O:18])[NH:5][C:6](=[O:14])[C:7]=2[CH2:12][S:11]1참가 물질
5
실험 절차
To a suspension of 2-(ethylthio)-7-methylthieno[3,4-d]pyrimidin-4(3H,5H,7H)-one (3.96 g, 17.3 mmol) in water (20 mL) was added 2.0 mL of conc. HCl and 4.0 mL of AcOH. The mixture was heated to reflux overnight then cooled and the precipitated solid collected by filtration, washed with water and methanol, evaporated and dried to obtain 7-methylthieno[3,4-d]pyrimidine-2,4(1H,3H,5H,7H)-dione as a white solid (2.52 g, 80%). Without further purification, the crude product was used directly in the next step.
후처리
- temperatureThe mixture was heated
- temperatureto reflux overnight
- temperaturethen cooled
- filtrationthe precipitated solid collected by filtration
- washwashed with water and methanol
- customevaporated
- customdried
출처 및 근거
- ORD 기록
- ord-0a4dc8363f3044749f2618383848e550
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09242993B2
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