1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester

반응식

[C:1]([O:5][C:6]([N:8]([CH2:18][CH3:19])[C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:20]CCCl>>[C:1]([O:5][C:6](=[O:7])[N:8]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:20])=[O:14])=[CH:11][N:10]=1)[CH2:18][CH3:19])([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 111,2-Dichloroethane

HCID 667695526-(((Tert-butoxy)carbonyl)(ethyl)amino)pyridine-3-carboxylic acid

생성물 1

HCID 86664610(5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester

실험 절차

6-(tert-Butoxycarbonyl-ethyl-amino)-nicotinic acid (6.40 g, 24.0 mmol) is taken up in 150 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (6.42 mL, 48.1 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.

후처리

concentrationThe reaction mixture is concentrated under reduced pressure
customthe crude product is used in the next step without purification

출처 및 근거

ORD 기록: ord-068c5445f3374fb9b532cbba1e893995
출처 데이터셋: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09243000B2

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