Formic Acid → N-Formyl-L-valine

HRID 595530노트

반응식

HRID 595530 반응식
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11].C(O)=O>>[CH:1]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11])=[O:3]

참가 물질

4

반응물 3

HCID 284Formic AcidHCID 6287L-ValineHCID 7918Acetic Anhydride

생성물 1

HCID 6950945N-Formyl-L-valine

실험 절차

Acetic anhydride (4 mL, 0.04 mol) was added dropwise to a solution of L-Valine (1 g, 8.35 mmol) in formic acid (12 mL, 0.32 mol) while stirring on ice. The mixture was then warmed up to RT and kept stirring for 24 hours before the solvent was removed by rotary evaporation under high vacuum. The formyl-valine was recrystallized from ethyl acetate and the desired product was obtained as a white solid. Yield: 0.78 g (64%) 1HNMR (500 MHz, [D6]Acetone, 25° C., TMS): δ=8.22 (s, 1H), 7.41 (b, 1H), 4.50 (m, 1H), 2.22 (m, 1H), 0.98 (m, 6H).

후처리

  1. stirringkept stirring for 24 hours before the solvent
  2. customwas removed by rotary evaporation under high vacuum
  3. customThe formyl-valine was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-cdbce83ac5c0480294fc2152e54b4207
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09243037B2

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