4-Fluoroaniline → Fluoroimide

HRID 596179

반응식

HRID 596179 반응식
[Cl:1]/[C:2](=[C:6](\[Cl:10])/[C:7](O)=[O:8])/[C:3](O)=[O:4].[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>O>[F:11][C:12]1[CH:18]=[CH:17][C:15]([N:16]2[C:3](=[O:4])[C:2]([Cl:1])=[C:6]([Cl:10])[C:7]2=[O:8])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 97314-Fluoroaniline2회HCID 6437972,3-Dichloromaleic acid

생성물 1

HCID 93228Fluoroimide수율 97.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

10 g (0.06 mol) of 2,3-dichloromaleic acid was dissolved in 100 ml of water. Then, to the resulting solution 5.55g (0.05 mol) of 4-fluoroaniline was added dropwise over a period of 5 min. at reflux temperatures under agitation. Upon addition of 4 -fluoroaniline, a white crystal separated out immediately but the reaction was allowed to preceed for two hours. After cooling, the crystal was separated by filtration and fully rinsed with water to obtain 12.7g (yield, 97.7%) of N-(4-fluorophenyl)-2,3-dichloromaleimide (Sample No. 1) having an average grain size of 10μ. An analysis by gas chromatography showed that the N-(4-fluorophenyl)-2,3-dichloromaleimide had a purity of 96.2%.

후처리

  1. temperatureat reflux temperatures under agitation
  2. customa white crystal separated out immediately
  3. temperatureAfter cooling
  4. customthe crystal was separated by filtration
  5. washfully rinsed with water

출처 및 근거

ORD 기록
ord-848a2ba1c81d40caa92dd79dae27eb59
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04010182

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