Benzene → 4-Fluoroanilinium 2,3-dichloromaleate

HRID 596185

반응식

HRID 596185 반응식
[Cl:1]/[C:2](=[C:6](\[Cl:10])/[C:7]([OH:9])=[O:8])/[C:3]([OH:5])=[O:4].[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1.C1C=CC=CC=1>>[Cl:1]/[C:2](=[C:6](\[Cl:10])/[C:7]([O-:9])=[O:8])/[C:3]([O-:5])=[O:4].[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH3+:16])=[CH:14][CH:13]=1.[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH3+:16])=[CH:14][CH:13]=1

참가 물질

4

반응물 3

HCID 241Benzene2회HCID 97314-FluoroanilineHCID 6437972,3-Dichloromaleic acid

생성물 1

HCID 867345124-Fluoroanilinium 2,3-dichloromaleate수율 98.7%

실험 절차

9.25g (0.05 mol) of 2,3-dichloromaleic acid was dissolved in 50 ml of benzene. To the resulting solution 20 ml of benzene containing 5.55g (0.05 mol) of 4-fluoroaniline was added dropwise over a period of 20 min. at temperatures of 15°-25° C under agitation. After completing the addition, the mixture was agitated at that temperature for 30 min. during which time crystals formed, which were separated by filtration and washed with benzene to obtain 14.7g of 4-fluoroanilinium 2,3-dichloromaleate in the form of white crystal at a yield of 98.7%. The crystal had a melting point (decomposition point) of 207° C and is expressed by the following formula: ##STR2## The results of elementary analysis were as follows:

후처리

  1. additionthe addition
  2. customformed
  3. customwhich were separated by filtration
  4. washwashed with benzene

출처 및 근거

ORD 기록
ord-5f974ed8abf444429e3d6d7a89afed69
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04010182

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