4-Fluoroaniline → Fluoroimide

HRID 596187

반응식

HRID 596187 반응식
[Cl:1]/[C:2](=[C:6](\[Cl:10])/[C:7](O)=[O:8])/[C:3](O)=[O:4].[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>O>[F:11][C:12]1[CH:18]=[CH:17][C:15]([N:16]2[C:3](=[O:4])[C:2]([Cl:1])=[C:6]([Cl:10])[C:7]2=[O:8])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 97314-FluoroanilineHCID 6437972,3-Dichloromaleic acid

생성물 1

HCID 93228Fluoroimide수율 98.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

18.5g (0.1 mol) of 2,3-dichloromaleic acid was dissolved in 120 ml of water. To the resulting solution 8.9g (0.08mol) of 4-fluoroaniline was added dropwise over a period of 5 min. at reflux temperatures under agitation. The mixture was then allowed to react for 2 hours at reflux temperatures. Upon cooling the reaction mixture, precipitated crystal was separated by filtration to obtain 20.3g of N-(4-fluorophenyl)-2,3-dichloromaleimide melting at 239°-240° C (not corrected) at a yield of 98.1%. An analysis by gas chromatography showed the product had a purity of 95.5%.

후처리

  1. temperatureat reflux temperatures under agitation
  2. customto react for 2 hours
  3. temperatureat reflux temperatures
  4. temperatureUpon cooling the reaction mixture
  5. customprecipitated crystal
  6. customwas separated by filtration

출처 및 근거

ORD 기록
ord-b1e8f4be274a499cb721d57cde8bddc1
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04010182

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