Glycine, N,N-diethyl-, hydrazide → 8-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

HRID 596357

반응식

HRID 596357 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=S)[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1.[CH2:20]([N:22]([CH2:25][C:26]([NH:28][NH2:29])=O)[CH2:23][CH3:24])[CH3:21]>C(O)CCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:26]([CH2:25][N:22]([CH2:23][CH3:24])[CH2:20][CH3:21])=[N:28][N:29]=[C:10]3[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1

참가 물질

4

반응물 2

HCID 200751Glycine, N,N-diethyl-, hydrazideHCID 826706Thionordiazepam

생성물 1

HCID 126123578-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

In the manner given in Preparation 1, a solution of 1,3-dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepine-2-thione and (diethylamino)acetic acid hydrazide in n-butyl alcohol is reacted to give 8-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine, which is recrystallized from ethyl acetateSkellysolve B hexanes and has a melting point of 131.5°-132.5° C. Anal. calcd. for C21H22ClN5 : C, 66.39; H, 5.84; Cl, 9.33; N, 18.44. Found: C, 66.20; H, 6.06; Cl, 9.29; N, 18.55. Preparation 8 8-Nitro-1-[(diethylamino)methyl]-6-phenyl4H-s-triazolo[4,3-a][1,4]benzodiazepine

후처리

  1. customIn the manner given in Preparation 1

출처 및 근거

ORD 기록
ord-63a151b67ff44768866d4a45edc6b71a
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04010177

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