2-(1H-benzimidazol-2-yl)isoindole-1,3-dione → N-(benzimidazol-2-yl)-2-(n-butoxycarbonyl)-benzamide

HRID 596574

반응식

HRID 596574 반응식
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20]>C(O)CCC>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[NH:10][C:14](=[O:15])[C:13]1[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=1[C:11]([O:15][CH2:14][CH2:13][CH2:12][CH3:11])=[O:20]

참가 물질

3

반응물 1

HCID 27557042-(1H-benzimidazol-2-yl)isoindole-1,3-dione

생성물 1

HCID 21449938N-(benzimidazol-2-yl)-2-(n-butoxycarbonyl)-benzamide

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

N-(Benzimidazol-2-yl)phthalimide (4 g.) in 200 ml. of n-butyl alcohol is heated at 115° C. for 35 minutes. On cooling, colorless needles form. These are removed by suction filtration, washed with butyl alcohol and finally with diethyl ether. After drying for three hours at 125° C. under vacuum, a yield of 2.5 g. of N-(benzimidazol-2-yl)-2-(n-butoxycarbonyl)-benzamide, m.p. 187° C., is obtained. Additional heating to higher temperatures causes a reclosure to the phthalimide and remelting which corresponds to the phthalimide, m.p. 267°-268° C.

후처리

  1. temperatureOn cooling
  2. customcolorless needles form
  3. customThese are removed by suction filtration
  4. washwashed with butyl alcohol and finally with diethyl ether
  5. customAfter drying for three hours at 125° C. under vacuum

출처 및 근거

ORD 기록
ord-95940ae3f397417aa28f55ef2a7ccea5
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04011236

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