2-(Pyridin-2-yloxy)ethanamine → N-[2-(2-Pyridyloxy)ethyl]3-Carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxamide

HRID 596598노트

반응식

HRID 596598 반응식
[C:1]([CH2:6][N:7]1[C:20](=[O:21])[C:19]2[C:10](=[N:11][C:12]3[C:17]([CH:18]=2)=[CH:16][C:15]([O:22][CH3:23])=[C:14]([O:24][CH3:25])[CH:13]=3)[N:9]=[C:8]1[C:26](OCC)=[O:27])([O:3][CH2:4][CH3:5])=[O:2].[N:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH2:38][CH2:39][NH2:40]>C(Cl)(Cl)Cl>[N:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[O:37][CH2:38][CH2:39][NH:40][C:26]([C:8]1[N:7]([CH2:6][C:1]([O:3][CH2:4][CH3:5])=[O:2])[C:20](=[O:21])[C:19]2[C:10]([N:9]=1)=[N:11][C:12]1[C:17]([CH:18]=2)=[CH:16][C:15]([O:22][CH3:23])=[C:14]([O:24][CH3:25])[CH:13]=1)=[O:27]

참가 물질

4

반응물 2

HCID 968902-(Pyridin-2-yloxy)ethanamineHCID 22752836ethyl 3-carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylate

생성물 1

HCID 21450316N-[2-(2-Pyridyloxy)ethyl]3-Carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxamide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of ethyl 3-carbethoxymethyl-7,8-dimethoxypyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylate (0.415 g., 1mM) and 2-(2-pyridyloxy)ethylamine (0.276 g., 2 mM) in chloroform (10 ml.) is refluxed for 24 hours. It is then cooled to room temperature and concentrated in vacuo. The residue, an oil, is crystallized by addition of ether until precipitation is complete. Yield = 0.41 g. (81%) of product; m.p. 170°-180° C.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue, an oil, is crystallized by addition of ether until precipitation

출처 및 근거

ORD 기록
ord-5118ef0be7d04fc99186124e4a15065f
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04011324

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