Benzoylacetone → Methanone, (3-methyl-1,4-dioxido-2-quinoxalinyl)phenyl-

HRID 596800

반응식

HRID 596800 반응식
[N+:1]1([O-:10])[O:5][N:4]=[C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=12.[C:11]([CH2:19][C:20](=O)[CH3:21])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].[Na+]>C(O)C>[C:11]([C:19]1[C:20]([CH3:21])=[N+:4]([O-:5])[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N+:1]=1[O-:10])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 7166BenzoylacetoneHCID 14798Sodium HydroxideHCID 68075Benzofuroxan

생성물 1

HCID 178428812Methanone, (3-methyl-1,4-dioxido-2-quinoxalinyl)phenyl-수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred suspension of 80 g. (0.59 mol.) of benzofurazan 1-oxide and 95 g. (0.59 mol.) of benzoylacetone in 1,000 ml. of ethanol was added 1.6 g. (0.04 mol.) of finely divided sodium hydroxide. The mixture became clear after about 30 minutes. Stirring was continued for a further 16 hours, and then the solid which had precipitated was collected by filtration. It was washed with ethanol, and dried to afford 153 g. (92% yield) of 2-benzoyl-3-methylquinoxaline 1,4-dioxide, m.p. 229°-231° C.

후처리

  1. additionTo a stirred suspension of 80 g
  2. waitwas continued for a further 16 hours
  3. customthe solid which had precipitated
  4. filtrationwas collected by filtration
  5. washIt was washed with ethanol
  6. customdried
  7. customto afford 153 g

출처 및 근거

ORD 기록
ord-1ea22345cfc7476cadffd9fb63a59e86
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04012385

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