Isobutyric anhydride → Methylene bisisobutyrate

반응식

[O:1]1[CH2:6][CH2:5][CH2:4]OO1.[C:7]([O:12][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])(=[O:11])C(C)C.Cl(O)(=O)(=O)=O.[C:23](=O)(O)[O-].[Na+]>>[C:13]([O:12][CH2:7][O:11][C:6](=[O:1])[CH:5]([CH3:23])[CH3:4])(=[O:17])[CH:14]([CH3:15])[CH3:16]

참가 물질

반응물 4

HCID 7346Isobutyric anhydride

HCID 24247Perchloric Acid

HCID 516892Sodium Bicarbonate

HCID 19593658CID 19593658

생성물 1

HCID 12851389Methylene bisisobutyrate

실험 절차

A 30-g (0.33 mol) sample of trioxane was added to a solution of 158 g (1 mol) isobutyric anhydride and 0.5 ml 70% perchloric acid over a 30-minute period at 65°-70° C. The reaction mixture was then stirred until the temperature decreased to 27° C. The reaction mixture was diluted with saturated sodium bicarbonate solution and extracted with ether. The ether extracts were dried over magnesium sulfate and evaporated under reduced pressure. The resulting residue was distilled on a 30-cm column to give 112 g of methylene bisisobutyrate, b.p. 43°-48° C. at 0.2-0.3 mm of Hg and 30 g of oxybis-methylene isobutyrate, b.p. 57°-63° C. at 0.2-0.3 mm of Hg.