Aluminum(III) Chloride → 6,7-Dichloro-5-hydroxy-2,2-dimethyl-indan-1-one
반응식
[CH3:1][C:2]1([CH3:16])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([O:11]C)[CH:8]=2)[C:3]1=[O:15].[Cl-].[Al+3].[Cl-].[Cl-]>CCCCCCC>[CH3:1][C:2]1([CH3:16])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([OH:11])[CH:8]=2)[C:3]1=[O:15]참가 물질
4
실험 절차
A stirred suspension of 2,2-dimethyl-5-methoxy-6,7-dichloro-1-indanone (12.2 g., 0.047 mole) and aluminum chloride (15.5 g., 0.116 mole) in heptane (500 ml.) is refluxed for 1 hour and cooled. The heptane is decanted from the reaction mixture and the solid residue is poured into ice (500 g.) and concentrated hydrochloric acid (50ml.). The product which separates (7.6 g.) melts at 273° C. after crystallization from nitromethane.
후처리
- temperatureis refluxed for 1 hour
- temperaturecooled
- customThe heptane is decanted from the reaction mixture
- additionthe solid residue is poured into ice (500 g.) and concentrated hydrochloric acid (50ml.)
- customafter crystallization from nitromethane
출처 및 근거
- ORD 기록
- ord-73910ee7da494611b814eded18e97b15
- 출처 데이터셋
- uspto-grants-1977_03
- 특허 번호
- US04012524
반응 노트
불러오는 중…