Diisobutylaluminum hydride → 3-(1-Methylpyrrolidin-2-yl)pyridine

HRID 59711

반응식

HRID 59711 반응식
[CH3:1][N:2]1[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[N:11][CH:10]=2)(C#N)[CH2:5][CH2:4][CH2:3]1.CC(C[AlH]CC(C)C)C>C1(C)C=CC=CC=1.CCCCCC>[N:11]1[CH:10]=[C:9]([CH:6]2[CH2:5][CH2:4][CH2:3][N:2]2[CH3:1])[CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 2

HCID 14487Diisobutylaluminum hydrideHCID 713334112'-Cyanonicotine

생성물 1

HCID 9423-(1-Methylpyrrolidin-2-yl)pyridine수율 4%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8058Hexane용매

반응 조건

온도
-78 °C

실험 절차

A solution of 2′-cyanonicotine 3 (324 mg, 1.73 mmol) in toluene (12.4 mL) was treated at −78° C. with DIBALH (8.65 mL of a 1.0 M solution in hexane, 8.65 mmol). After the reaction mixture had been stirred for an additional 3 h at −78° C., it was quenched by slow addition of saturated aqueous solution of NH4Cl. The resulting mixture was allowed to warm to room temperature. The organic layer was separated and the aqueous layer was extracted with methylene chloride. The combined organic extracts were dried over MgSO4 and concentrated in vacuo. The crude mixture was purified by flash chromatography on silica gel (CH2Cl2/CH3OH/NH4OH concd 95:5:0.1) to give (±)-2′-aminomethylnicotine 8 as a clear oil (195.1 mg, 1.02 mmol, 59%) as well as nicotine (11 mg, 0.07 mmol, 4%). 1H NMR (300 MHz, CDCl3): δ=8.60 (d, 1H, J=2.7 Hz, ArH), 8.48 (dd, 1H, J=1.8, 4.8 Hz, ArH), 7.64 (dt, 1H, J=8.1, 1.8 Hz, ArH), 7.28 (ddd, 1H, J=8.1, 4.8, 0.9 Hz, ArH), 3.21 (d, 1H, J=12.9 Hz), 3.03 (d, 1H, J=12.9 Hz), 3.00 (m, 1H), 2.74 (m, 1H), 2.18 (m, 2H), 2.17 (s, 3H, NCH3), 1.93 (m, 2H), 1.32 (bs, 2H, NH2). —13C NMR (75.3 MHz, CDCl3): δ=149.1 (CH), 148.0 (CH), 138.3 (C), 135.0 (CH), 123.2 (CH), 68.0 (C), 54.8 (CH2), 46.5 (CH2), 36.5 (CH2), 35.5 (CH3), 22.5 (CH2). HRMS (ESI) m/z: found for [M+H]+ 192.1490. Calcd for C11H17N3 192.1495.

후처리

  1. customit was quenched by slow addition of saturated aqueous solution of NH4Cl
  2. temperatureto warm to room temperature
  3. customThe organic layer was separated
  4. extractionthe aqueous layer was extracted with methylene chloride
  5. dry with materialThe combined organic extracts were dried over MgSO4
  6. concentrationconcentrated in vacuo
  7. customThe crude mixture was purified by flash chromatography on silica gel (CH2Cl2/CH3OH/NH4OH concd 95:5:0.1)

출처 및 근거

ORD 기록
ord-ba065c73e331418087e05d3e95e1a7a5
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440948B2

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