p-Toluenesulfonic acid → 2,5-Dimethyl-3-furancarboxanilide

HRID 597258

반응식

HRID 597258 반응식
C(O[CH:5]([CH3:8])[CH:6]=O)(=O)C.[C:9]([NH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:14])[CH2:10][C:11]([CH3:13])=[O:12].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[CH3:13][C:11]1[O:12][C:5]([CH3:8])=[CH:6][C:10]=1[C:9]([NH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:14]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 7592AcetoacetanilideHCID 907282-(Acetyloxy)propanal

생성물 1

HCID 342812,5-Dimethyl-3-furancarboxanilide

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 24 parts of α-acetoxypropionaldehyde, 35.4 parts of acetoacetanilide and 2 parts of p-toluenesulfonic acid in 100 parts of benzene is kept for 3 hours at 40° C and then boiled under reflux for 1 hour. Adopting the isolation procedure described in Example 1 there is obtained 41.8 parts of 2,5-dimethylfuran-3-carboxanilide having a melting point of 92° to 93° C.

후처리

  1. temperatureunder reflux for 1 hour

출처 및 근거

ORD 기록
ord-5f59a1c4dbd54bfb931d73bada34606e
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04013684

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