Hydrochloric Acid → Chloromethylphthalimide

반응식

[ClH:1].O[CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]>>[Cl:1][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]

참가 물질

반응물 2

HCID 313Hydrochloric Acid3회

HCID 8354N-(hydroxymethyl)phthalimide

생성물 1

HCID 87154Chloromethylphthalimide

실험 절차

reacting said mixture at a temperature of from about 45° to about 75° C at a pressure of from about 0 psig to about 50 psig while intimately contacting said reacting mixture with anhydrous HCl at a rate of from approximately 15 to approximately 65 pounds HCl per hour per pound-mole of N-hydroxymethyl phthalimide used to form the mixture in step (a), to maintain the concentration of said aqueous HCl at 35 to 40 wt.%, to form N-chloromethyl phthalimide in an aqueous-organic mixture;

후처리

customof from about 45° to about 75° C
customto form the mixture in step (a)

출처 및 근거

ORD 기록: ord-5a6163d7f1c243ed9c96af6ef0a01adf
출처 데이터셋: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04013685

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