Sodium Hydroxide → 5-[p-(1-Cyclooctenyl)-phenoxy]-pentanoic acid

HRID 597305

반응식

HRID 597305 반응식
[OH-].[Na+].C([O:5][C:6](=[O:26])[CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH:19]=2)=[CH:14][CH:13]=1)C>C(O)C>[C:18]1([C:15]2[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][CH2:8][CH2:7][C:6]([OH:26])=[O:5])=[CH:17][CH:16]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH:19]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 543745795-[p-(1-Cyclooctenyl)-phenoxy]-pentanoic acid ethyl ester

생성물 1

HCID 545179805-[p-(1-Cyclooctenyl)-phenoxy]-pentanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

20 ml of 2 N sodium hydroxide solution are added to a solution of 15 g of 5-[p-(1-cyclooctenyl)-phenoxy]-pentanoic acid ethyl ester in 150 ml of ethanol and the mixture is left to stand at room temperature for 48 hours. It is then evaporated in vacuo to a volume of about 30 ml and the evaporation residue is distributed, at 5° C, between 100 ml of 2 N hydrochloric acid and twice 200 ml of ether. The organic phases are washed until neutral, dried over sodium sulphate and evaporated in vacuo. Crystallisation of the evaporation residue from ether-petroleum ether gives 5-[p-(1-cyclooctenyl)-phenoxy]-pentanoic acid of melting point 94- 96° C.

후처리

  1. waitthe mixture is left
  2. customIt is then evaporated in vacuo to a volume of about 30 ml
  3. customis distributed, at 5° C, between 100 ml of 2 N hydrochloric acid and twice 200 ml of ether
  4. washThe organic phases are washed until neutral,
  5. dry with materialdried over sodium sulphate
  6. customevaporated in vacuo
  7. customCrystallisation of the evaporation residue from ether-petroleum ether

출처 및 근거

ORD 기록
ord-d7d3bf330b294cecb6711aba7ae304d3
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04013708

연결된 노트

불러오는 중…