Diethyl Malonate → HCID 86602522, 화합물
반응식
[Na:1].[C:2]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]>C(O)C>[C:4]([O:6][CH2:7][CH3:8])(=[O:5])[CH2:3][C:2]([O:10][CH2:11][CH3:12])=[O:9].[Na:1]참가 물질
4
실험 절차
The compound ##EQU36## is prepared by adding 44 grams sodium metal to 900 ml. ethanol and adding 320 grams diethyl malonate to form a slurry of sodium diethyl malonate. To this slurry, 88 grams of ethylene oxide in 300 ml. ethanol is added, the temperature being maintained in the range of 40° to 45° C. The mixture is stirred for 14 hours at a temperature of 25° C and 120 ml. glacial acetic acid is added to form the compound (1). The ethanol is distilled from the slurry under reduced pressure; 500 ml. water is added to the residue to dissolve sodium acetate; the organic product phase is separated, dissolved in ether, washed with water, dried and stripped of ether, and distilled to yield purified ##EQU37## Step 2: