Bromine → N-[3-(Bromoacetyl)phenyl]acetamide

HRID 597567

반응식

HRID 597567 반응식
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[NH:7][C:8](=[O:10])[CH3:9])(=[O:3])[CH3:2].[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][CH2:2][C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[NH:7][C:8](=[O:10])[CH3:9])=[O:3]

참가 물질

4

반응물 2

HCID 24408BromineHCID 3462023'-Acetamidoacetophenone

생성물 1

HCID 12431847N-[3-(Bromoacetyl)phenyl]acetamide

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a stirred solution of 110.0 g. (0.62 mole) of 3'-acetylacetanilide in 2400 ml. of chloroform is added dropwise a solution of 33.0 ml. (102.9 g; 0.644 mole) of bromine in 240 ml. of chloroform. The solution is stirred one hour and the resultant precipitate is then filtered, washed with ether and dried. The solid is stirred in a large volume of water to give an oily precipitate which crystallizes on further stirring. The solid is filtered, washed with water and then 2-propanol. The dried product weighs 148.34 g., and is recrystallized from 2-propanol to give the product, melting point 108.5°-110° C. Analysis: Calcd, for C10H10BrNO2 : Calcd: C, 46.90; H, 3.94; Br, 31.20; N, 5.47. Found: C, 47.12; H, 3.94; Br, 31.21; N, 5.47.

후처리

  1. filtrationthe resultant precipitate is then filtered
  2. washwashed with ether
  3. customdried
  4. stirringThe solid is stirred in a large volume of water
  5. customto give an oily precipitate which
  6. customcrystallizes on further stirring
  7. filtrationThe solid is filtered
  8. washwashed with water
  9. custom, and is recrystallized from 2-propanol
  10. customto give the product, melting point 108.5°-110° C

출처 및 근거

ORD 기록
ord-de425ded540241f9953b6087d2c3a356
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04014892

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