Hydrazine hydrate (1:1) → 3,5-Diphenyl-4-methoxypyrazole

HRID 597584

반응식

HRID 597584 반응식
CC(C(C1C=CC=CC=1)=O)=CC1C=CC=CC=1.O.NN.[C:21]1([C:27]2[NH:28][NH:29][CH:30]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:31]=2[O:32][CH3:33])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.N1CC=CN1>[Pd]>[C:21]1([C:27]2[C:31]([O:32][CH3:33])=[C:30]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[NH:29][N:28]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

6

반응물 4

HCID 24654Hydrazine hydrate (1:1)HCID 99812alpha-MethylchalconeHCID 41560032,3-dihydro-1H-pyrazoleHCID 681174383,5-Diphenyl-4-methoxypyrazoline

생성물 1

HCID 124985213,5-Diphenyl-4-methoxypyrazole

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Following the procedure of Example 1 but substituting α-methoxychalcone for α-methylchalcone, and reacting the same with hydrazine hydrate, there is prepared 3,5-diphenyl-4-methoxypyrazoline. The so-formed pyrazoline is then reacted with Pd/C at reflux to obtain 3,5-diphenyl-4-methoxypyrazole in good yield.

후처리

  1. temperatureat reflux

출처 및 근거

ORD 기록
ord-f790a37f3f694e10be2af2feedb1248f
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04014896

연결된 노트

불러오는 중…