2-(Benzyloxy)-3,5-dibromobenzaldehyde → HCID 178512744, 화합물

HRID 597721노트

반응식

HRID 597721 반응식
Cl.[NH2:2][NH:3][C:4]([NH:6][NH2:7])=[NH:5].[CH2:8]([O:15][C:16]1[C:23]([Br:24])=[CH:22][C:21]([Br:25])=[CH:20][C:17]=1[CH:18]=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[H][H]>Cl>[Br:24][C:23]1[C:16]([O:15][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:17]([CH:20]=[C:21]([Br:25])[CH:22]=1)[CH:18]=[N:2][NH:3][C:4]([NH:6][N:7]=[CH:18][C:17]1[CH:20]=[C:21]([Br:25])[CH:22]=[C:23]([Br:24])[C:16]=1[O:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[NH:5]

참가 물질

5

반응물 3

HCID 14943372-(Benzyloxy)-3,5-dibromobenzaldehydeHCID 178418361HCID 178418361, 화합물HCID 178479531HCID 178479531, 화합물

생성물 1

HCID 178512744HCID 178512744, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

To a mixture of 2.1 grams (0.015 mole) of N,N'-diaminoguanidine, hydrochloride in 50 milliliters of 2B-ethanol and 2.0 milliliters of concentrated hydrochloric acid was added 11.1 grams (0.03 mole) of 2-benzyloxy-3,5-dibromobenzaldehyde. The mixture was stirred and heated to reflux temperature and maintained at this temperature overnight. At the completion of the reaction, the insoluble crystals contained in the reaction mixture were removed by filtration and dried under reduced pressure. The solid crude 1,3-bis[((3,5-dibromo-2-benzyloxybenzylidene)-amino]guanidine, hydrochloride product was mixed with 250 milliliters of benzene refluxed, recovered by filtration and dried. The product was obtained in a yield of 11.3 grams and melted at 217°-218° C. Upon analysis, the product was found to have carbon, hydrogen and nitrogen contents of 41.83, 3.00 and 8.48 percent, respectively, as compared with the theoretical contents of 41.98, 2.92 and 8.44 percent, respectively, calculated for the abovenamed structure.

후처리

  1. temperatureheated
  2. temperatureto reflux temperature
  3. temperaturemaintained at this temperature overnight
  4. customAt the completion of the reaction
  5. customwere removed by filtration
  6. customdried under reduced pressure
  7. additionThe solid crude 1,3-bis[((3,5-dibromo-2-benzyloxybenzylidene)-amino]guanidine, hydrochloride product was mixed with 250 milliliters of benzene
  8. temperaturerefluxed
  9. filtrationrecovered by filtration
  10. customdried
  11. customThe product was obtained in a yield of 11.3 grams and melted at 217°-218° C

출처 및 근거

ORD 기록
ord-fde0dd452c434535aee026afdb908733
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04015016

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