Hydrochloric Acid → 1-(3'-Formylamino-phenyl)-2-amino-propane hydrochloride

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH2:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[ClH:12].[CH3:13][OH:14]>>[ClH:12].[CH:13]([NH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH2:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1)=[O:14]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 204423703-(2-Aminopropyl)aniline

생성물 1

HCID 214462101-(3'-Formylamino-phenyl)-2-amino-propane hydrochloride

실험 절차

255 gm of 1-(3'-amino-phenyl)-2-amino-propane were dissolved in methanol, and the solution was acidified with ethereal hydrochloric acid. The monohydrochloride thus obtained was refluxed for 2 hours in 225 ml of formic acid, and the reaction mixture was then evaporated in a water aspirator vacuum, leaving a yellow oil which solidified upon being digested with ether. The solidified product was recrystallized from ethanol by addition of ether, yielding the compound of the formula ##STR15## which had a melting point of 150°-153° C.

출처 및 근거

ORD 기록: ord-e8d47a72ce1847918b8c9754d0c6f5c5
출처 데이터셋: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04015011

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