1-(3'-Nitro-phenyl)-2-formylamino-propane → 1-(3'-Aminophenyl)-2-formylamino-propane

HRID 597733노트

반응식

HRID 597733 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][CH:11]([NH:13][CH:14]=[O:15])[CH3:12])[CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 1

HCID 213274321-(3'-Nitro-phenyl)-2-formylamino-propane

생성물 1

HCID 213274251-(3'-Aminophenyl)-2-formylamino-propane

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

5.2 gm of 1-(3'-nitro-phenyl)-2-formylamino-propane was hydrogenated in methanol in the presence of Raney nickel at atmospheric pressure and room temperature. Thereafter, the catalyst was filtered off, the solvent was evaporated from the filtrate, and the residue was chromatographed on a silicagel column, using methanol/chloroform (2:8) as the flow agent. The eluate was evaporated, and the residue was recrystallized from ethyl acetate, yielding 1-(3'-aminophenyl)-2-formylamino-propane which had a melting point of 107° -108° C.

후처리

  1. filtrationThereafter, the catalyst was filtered off
  2. customthe solvent was evaporated from the filtrate
  3. customthe residue was chromatographed on a silicagel column
  4. customThe eluate was evaporated
  5. customthe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-a17087da65784c37a316599519ad01b6
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04015011

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