Triethylamine → HCID 67052453, 화합물

HRID 598036

반응식

HRID 598036 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[N:4][CH:3]=1.C(N(CC)CC)C.[NH2:23][CH2:24][C:25]1([OH:30])[CH2:29][CH2:28][CH2:27][CH2:26]1>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:23][CH2:24][C:25]3([OH:30])[CH2:29][CH2:28][CH2:27][CH2:26]3)=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[N:9]2)=[N:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 130512021-(Aminomethyl)cyclopentan-1-olHCID 574578377-Bromo-4-chloro-3-nitro[1,5]naphthyridine

생성물 1

HCID 67052453HCID 67052453, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매2회

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온도
0 °C

실험 절차

A suspension of 7-bromo-4-chloro-3-nitro[1,5]naphthyridine (54.42 g, 188.6 mmol) in chloroform (820 mL) was cooled to 0° C., and triethylamine (105 mL, 755 mmol) was added. A solution of 1-(aminomethyl)cyclopentanol (28.25 g, 245.2 mmol) in chloroform (272 mL) was added slowly over a period of 15 minutes. The reaction was allowed to warm to room temperature and stirred for 30 minutes. The solution was washed sequentially with water (500 mL) and saturated aqueous sodium bicarbonate (750 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure to provide 1-{[(7-bromo-3-nitro[1,5]naphthyridin-4-yl)amino]methyl}cyclopentanol.

후처리

  1. temperatureto warm to room temperature
  2. washThe solution was washed sequentially with water (500 mL) and saturated aqueous sodium bicarbonate (750 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c3aa6b0b83bb485ca8fb2bfacae7a3f6
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897609B2

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