Acetic Acid → 5-methoxy-3-methyl-1H-quinazoline-2,4-dione
반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([NH:16][CH3:17])=[O:15])[C:4]=1[C:5](NC)=[O:6].[OH-].[Na+].C(O)(=O)C>O.C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5](=[O:6])[N:16]([CH3:17])[C:14](=[O:15])[NH:13]2참가 물질
6
실험 절차
A mixture of 2-Methoxy-N-methyl-6-[[(methylamino)carbonyl]amino]benzamide (200 mg, 0.843 mmol), 5% sodium hydroxide solution in water (8 ml) and ethanol (4 ml) was refluxed for 1 h. The solution was allowed to cool and then acidified with acetic acid. The aqueous solution was extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate, and concentrated under vacuum to afford 168 mg (97%) of the title compound.
후처리
- temperaturewas refluxed for 1 h
- temperatureto cool
- extractionThe aqueous solution was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-7be018ffceb44458a5f7a83ce0c4a6e1
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07897607B2
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