Sodium Hydroxide → HCID 136400718, 화합물
반응식
[I:1][C:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([NH:12]C(=O)C(C)(C)C)=[N:6][C:5]=2[N:4]([CH3:19])[CH:3]=1.[OH-].[Na+]>O1CCCC1>[NH2:12][C:7]1[NH:8][C:9](=[O:11])[C:10]2[C:2]([I:1])=[CH:3][N:4]([CH3:19])[C:5]=2[N:6]=1참가 물질
4
실험 절차
To a solution of N-(5-iodo-7-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (17.9 g, 47.8 mmol) in tetrahydrofuran (150 ml) was added 2N aqueous solution of sodium hydroxide (57.4 ml, 115 mmol) at 0° C., and the mixture was refluxed for 5 hours After cooling, the solvent was evaporated in vacuo. The suspension was neutralized with 1N hydrochloric acid, and the resulting crystals were collected by filtration and washed with water to give 13.3 g (96%) of the title compound.
후처리
- temperaturethe mixture was refluxed for 5 hours
- temperatureAfter cooling
- customthe solvent was evaporated in vacuo
- filtrationthe resulting crystals were collected by filtration
- washwashed with water
출처 및 근거
- ORD 기록
- ord-03f81af180f64f519f71862f2325fda5
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07897607B2
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