Water → HCID 57438270, 화합물

HRID 598404노트

반응식

HRID 598404 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][NH:5][C:4](=[O:11])[CH:3]=1.[F:12][C:13]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:14]=1[NH2:15].O>CCO.Cl>[F:12][C:13]1[CH:19]=[C:18]([I:20])[CH:17]=[CH:16][C:14]=1[NH:15][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][NH:5][C:4](=[O:11])[CH:3]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 1856942-Fluoro-4-iodoanilineHCID 426090674-Chloro-5-nitropyridin-2(1H)-one

생성물 1

HCID 57438270HCID 57438270, 화합물수율 45%

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

To the mixture of 4-chloro-5-nitropyridin-2(1H)-one (90.1 mg, 0.517 mmol) and 2-fluoro-4-iodoaniline (137.5 mg, 0.58 mmol) dissolved in EtOH (5 mL) was added 6 drops of HCl (37% wt in water). The reaction vessel was closed and heated at 90° C. for 48 hours. After cooling to room temperature, water was added, and the solution was stirred at room temperature for 20 min. The precipitate was filtered, washed with water, dried under vacuum and used for the next reaction without further purification. (87.3 mg, 45% yield).

후처리

  1. customThe reaction vessel was closed
  2. temperatureAfter cooling to room temperature
  3. filtrationThe precipitate was filtered
  4. washwashed with water
  5. customdried under vacuum
  6. customused for the next reaction without further purification

출처 및 근거

ORD 기록
ord-62f399ff62994252ba8f20e2dd55170b
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897624B2

반응 노트

불러오는 중…